1svb

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[[Image:1svb.gif|left|200px]]
[[Image:1svb.gif|left|200px]]
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{{Structure
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|PDB= 1svb |SIZE=350|CAPTION= <scene name='initialview01'>1svb</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1svb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1svb| PDB=1svb | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1svb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svb OCA], [http://www.ebi.ac.uk/pdbsum/1svb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1svb RCSB]</span>
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}}
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'''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS'''
'''ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Rey, F A.]]
[[Category: Rey, F A.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:10:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:25 2008''
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Revision as of 06:10, 3 May 2008

Image:1svb.gif

Template:STRUCTURE 1svb

ENVELOPE GLYCOPROTEIN FROM TICK-BORNE ENCEPHALITIS VIRUS


Overview

The crystallographically determined structure of a soluble fragment from the major envelope protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a direction that would be parallel to the viral membrane. Residues that influence binding of monoclonal antibodies lie on the outward-facing surface of the protein. The clustering of mutations that affect virulence in various flaviviruses indicates a possible receptor binding site and, together with other mutational and biochemical data, suggests a picture for the fusion-activating, conformational change triggered by low pH.

About this Structure

1SVB is a Single protein structure of sequence from Tick-borne encephalitis virus. Full crystallographic information is available from OCA.

Reference

The envelope glycoprotein from tick-borne encephalitis virus at 2 A resolution., Rey FA, Heinz FX, Mandl C, Kunz C, Harrison SC, Nature. 1995 May 25;375(6529):291-8. PMID:7753193 Page seeded by OCA on Sat May 3 09:10:34 2008

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OCA

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