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1svz
From Proteopedia
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'''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease''' | '''Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVZ OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721587 15721587] | Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721587 15721587] | ||
| - | [[Category: Mus musculus]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Bentley, G A.]] | [[Category: Bentley, G A.]] | ||
[[Category: Brynda, J.]] | [[Category: Brynda, J.]] | ||
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[[Category: Rezacova, P.]] | [[Category: Rezacova, P.]] | ||
[[Category: Sedlacek, J.]] | [[Category: Sedlacek, J.]] | ||
| - | [[Category: | + | [[Category: Antibody-antigen complex]] |
| - | [[Category: | + | [[Category: Hiv inhibiting antibody]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:12:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:12, 3 May 2008
Crystal structure of the single-chain Fv fragment 1696 in complex with the epitope peptide corresponding to N-terminus of HIV-2 protease
Overview
The monoclonal antibody 1696, elicited by HIV-1 protease, inhibits the activity of both HIV-1 and HIV-2 proteases with inhibition constants in the low nanomolar range. The antibody cross-reacts with peptides derived from the N-terminal region of both proteases. The crystal structure of the recombinant single-chain Fv fragment of 1696 complexed with an N-terminal peptide from the HIV-2 protease has been determined at 1.88A resolution. Interactions of the peptide with scFv1696 are compared with the previously reported structure of scFv1696 in complex with the corresponding peptide from HIV-1 protease. The origin of cross-reactivity of mAb1696 with HIV proteases is discussed.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide., Rezacova P, Brynda J, Lescar J, Fabry M, Horejsi M, Sieglova I, Sedlacek J, Bentley GA, J Struct Biol. 2005 Mar;149(3):332-7. PMID:15721587 Page seeded by OCA on Sat May 3 09:12:06 2008
