5u3v
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human PPARdelta ligand-binding domain in complexed with specific agonist 6== | |
| - | + | <StructureSection load='5u3v' size='340' side='right' caption='[[5u3v]], [[Resolution|resolution]] 1.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5u3v]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U3V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7TY:6-[2-({CYCLOPENTYL[4-(FURAN-3-YL)BENZENE-1-CARBONYL]AMINO}METHYL)PHENOXY]HEXANOIC+ACID'>7TY</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5u3q|5u3q]], [[5u3r|5u3r]], [[5u3s|5u3s]], [[5u3t|5u3t]], [[5u3u|5u3u]], [[5u3w|5u3w]], [[5u3x|5u3x]], [[5u3y|5u3y]], [[5u3z|5u3z]], [[5u40|5u40]], [[5u41|5u41]], [[5u42|5u42]], [[5u44|5u44]], [[5u45|5u45]], [[5u46|5u46]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u3v OCA], [http://pdbe.org/5u3v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u3v RCSB], [http://www.ebi.ac.uk/pdbsum/5u3v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u3v ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN]] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Atkins, A R]] | ||
| + | [[Category: Baiga, T J]] | ||
| + | [[Category: Bowman, M E]] | ||
| + | [[Category: Clair, J J.La]] | ||
[[Category: Downes, M]] | [[Category: Downes, M]] | ||
| - | [[Category: | + | [[Category: Evans, R M]] |
| - | [[Category: | + | [[Category: Noel, J P]] |
| - | [[Category: | + | [[Category: Richard, S B]] |
| - | [[Category: Stockley-Noel, T | + | [[Category: Stockley-Noel, T A]] |
| + | [[Category: Wu, C C]] | ||
| + | [[Category: Agonist]] | ||
| + | [[Category: Ligand-binding domain]] | ||
| + | [[Category: Ppardelta]] | ||
| + | [[Category: Protein binding-activator complex]] | ||
Revision as of 16:45, 22 March 2017
Human PPARdelta ligand-binding domain in complexed with specific agonist 6
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