1syo

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[[Image:1syo.gif|left|200px]]
[[Image:1syo.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1syo |SIZE=350|CAPTION= <scene name='initialview01'>1syo</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1syo", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M6P:ALPHA-D-MANNOSE-6-PHOSPHATE'>M6P</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= IGF2R, M6P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])
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|DOMAIN=
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{{STRUCTURE_1syo| PDB=1syo | SCENE= }}
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|RELATEDENTRY=[[1q25|1Q25]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1syo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syo OCA], [http://www.ebi.ac.uk/pdbsum/1syo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1syo RCSB]</span>
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}}
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'''N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate'''
'''N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate'''
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[[Category: Kim, J J.P.]]
[[Category: Kim, J J.P.]]
[[Category: Olson, L J.]]
[[Category: Olson, L J.]]
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[[Category: lectin]]
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[[Category: Lectin]]
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[[Category: mannose 6-phosphate]]
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[[Category: Mannose 6-phosphate]]
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[[Category: receptor]]
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[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:17:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:48:45 2008''
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Revision as of 06:17, 3 May 2008

Image:1syo.gif

Template:STRUCTURE 1syo

N-terminal 3 domains of CI-MPR bound to mannose 6-phosphate


Overview

The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in the trafficking of newly synthesized mannose 6-phosphate-containing acid hydrolases to the lysosome. The receptor contains two high affinity carbohydrate recognition sites within its 15-domain extracytoplasmic region, with essential residues for carbohydrate recognition located in domain 3 and domain 9. Previous studies have shown that these two sites are distinct with respect to carbohydrate specificity. In addition, expression of truncated forms of the CI-MPR demonstrated that domain 9 can be expressed as an isolated domain, retaining high affinity (Kd approximately 1 nm) carbohydrate binding, whereas expression of domain 3 alone resulted in a protein capable of only low affinity binding (Kd approximately 1 microm) toward a lysosomal enzyme. In the current report the crystal structure of the N-terminal 432 residues of the CI-MPR, encompassing domains 1-3, was solved in the presence of bound mannose 6-phosphate. The structure reveals the unique architecture of this carbohydrate binding pocket and provides insight into the ability of this site to recognize a variety of mannose-containing sugars.

About this Structure

1SYO is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor., Olson LJ, Dahms NM, Kim JJ, J Biol Chem. 2004 Aug 6;279(32):34000-9. Epub 2004 May 28. PMID:15169779 Page seeded by OCA on Sat May 3 09:17:18 2008

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