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5ug5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR SOLUTION STRUCTURE OF THE ALPHA-CONOTOXIN GID MUTANT V13Y== | |
| - | + | <StructureSection load='5ug5' size='340' side='right' caption='[[5ug5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ug5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UG5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ug3|5ug3]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ug5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ug5 OCA], [http://pdbe.org/5ug5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ug5 RCSB], [http://www.ebi.ac.uk/pdbsum/5ug5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ug5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CA1D_CONGE CA1D_CONGE]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin reversibly blocks alpha-3-beta-2 (IC(50)=3.1-5.1 nM), alpha-7 (IC(50)=4.5-5.1 nM), and alpha-4-beta-2 (IC(50)=128.6-390 nM) nAChRs.<ref>PMID:12419800</ref> <ref>PMID:15929983</ref> <ref>PMID:19098004</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bonneau, R]] | ||
| + | [[Category: Filipenko, P]] | ||
| + | [[Category: Gorson, J]] | ||
| + | [[Category: Heizmann, A]] | ||
| + | [[Category: Holford, M]] | ||
| + | [[Category: Hussein, A]] | ||
| + | [[Category: Kuryatov, A]] | ||
| + | [[Category: Leffler, A E]] | ||
| + | [[Category: Lindstrom, J]] | ||
| + | [[Category: Lyskov, S]] | ||
| + | [[Category: Nicke, A]] | ||
| + | [[Category: Poget, S F]] | ||
| + | [[Category: Powell, S R]] | ||
| + | [[Category: Rudy, B]] | ||
| + | [[Category: Zebroski, H A]] | ||
| + | [[Category: Neurotoxin]] | ||
| + | [[Category: Toxin]] | ||
Revision as of 09:41, 13 September 2017
NMR SOLUTION STRUCTURE OF THE ALPHA-CONOTOXIN GID MUTANT V13Y
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Categories: Bonneau, R | Filipenko, P | Gorson, J | Heizmann, A | Holford, M | Hussein, A | Kuryatov, A | Leffler, A E | Lindstrom, J | Lyskov, S | Nicke, A | Poget, S F | Powell, S R | Rudy, B | Zebroski, H A | Neurotoxin | Toxin
