1syy

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[[Image:1syy.gif|left|200px]]
[[Image:1syy.gif|left|200px]]
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{{Structure
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|PDB= 1syy |SIZE=350|CAPTION= <scene name='initialview01'>1syy</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1syy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonucleoside-diphosphate_reductase Ribonucleoside-diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.4.1 1.17.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NRDB, CT828 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=813 Chlamydia trachomatis])
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|DOMAIN=
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{{STRUCTURE_1syy| PDB=1syy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1syy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1syy OCA], [http://www.ebi.ac.uk/pdbsum/1syy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1syy RCSB]</span>
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}}
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'''Crystal structure of the R2 subunit of ribonucleotide reductase from Chlamydia trachomatis'''
'''Crystal structure of the R2 subunit of ribonucleotide reductase from Chlamydia trachomatis'''
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[[Category: Stenmark, P.]]
[[Category: Stenmark, P.]]
[[Category: Voevodskaya, N.]]
[[Category: Voevodskaya, N.]]
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[[Category: diiron]]
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[[Category: Diiron]]
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[[Category: immune evasion]]
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[[Category: Immune evasion]]
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[[Category: iron coupled radical]]
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[[Category: Iron coupled radical]]
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[[Category: oxygen activation]]
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[[Category: Oxygen activation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:17:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:48:49 2008''
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Revision as of 06:17, 3 May 2008

Image:1syy.gif

Template:STRUCTURE 1syy

Crystal structure of the R2 subunit of ribonucleotide reductase from Chlamydia trachomatis


Overview

Ribonucleotide reductase (RNR) synthesizes the deoxyribonucleotides for DNA synthesis. The R2 protein of normal class I ribonucleotide reductases contains a diiron site that produces a stable tyrosyl free radical, essential for enzymatic activity. Structural and electron paramagnetic resonance studies of R2 from Chlamydia trachomatis reveal a protein lacking a tyrosyl radical site. Instead, the protein yields an iron-coupled radical upon reconstitution. The coordinating structure of the diiron site is similar to that of diiron oxidases/monoxygenases and supports a role for this radical in the RNR mechanism. The specific ligand pattern in the C. trachomatis R2 metal site characterizes a new group of R2 proteins that so far has been found in eight organisms, three of which are human pathogens.

About this Structure

1SYY is a Single protein structure of sequence from Chlamydia trachomatis. Full crystallographic information is available from OCA.

Reference

The radical site in chlamydial ribonucleotide reductase defines a new R2 subclass., Hogbom M, Stenmark P, Voevodskaya N, McClarty G, Graslund A, Nordlund P, Science. 2004 Jul 9;305(5681):245-8. PMID:15247479 Page seeded by OCA on Sat May 3 09:17:45 2008

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