1t1n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1t1n.jpg|left|200px]]
[[Image:1t1n.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1t1n |SIZE=350|CAPTION= <scene name='initialview01'>1t1n</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1t1n", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1t1n| PDB=1t1n | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t1n OCA], [http://www.ebi.ac.uk/pdbsum/1t1n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t1n RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN'''
'''CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN'''
Line 29: Line 26:
[[Category: Vitagliano, L.]]
[[Category: Vitagliano, L.]]
[[Category: Zagari, A.]]
[[Category: Zagari, A.]]
-
[[Category: hemoglobin]]
+
[[Category: Hemoglobin]]
-
[[Category: oxygen transport]]
+
[[Category: Oxygen transport]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:23:42 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:49:54 2008''
+

Revision as of 06:23, 3 May 2008

Image:1t1n.jpg

Template:STRUCTURE 1t1n

CRYSTAL STRUCTURE OF CARBONMONOXY HEMOGLOBIN


Overview

As new structural data have become available, somewhat contrasting explanations of the Root effect in fish haemoglobins (Hb) have been provided. Hb 1 of the Antarctic fish Trematomus newnesi has a nearly pH-independent oxygen affinity, in spite of 95 % sequence identity with Hb 1 of Trematomus (previously named Pagothenia) bernacchii that has a strong Root effect. Here, the 2.2 A R-state structure of Trematomus newnesi Hb 1 is presented. The structure is similar to that of Root effect fish Hbs from Spot and T. bernacchii, suggesting that the differences in the pH dependence cannot be related to the modulation of the R-state. In comparison to T. bernacchii Hb 1, the role of the three mutations Thr41 (C6)alpha-->Ile, Ala97 (G3)alpha-->Ser and His41 (C7)beta-->Tyr at the alpha1beta2-interface is discussed.

About this Structure

1T1N is a Protein complex structure of sequences from Trematomus newnesi. Full crystallographic information is available from OCA.

Reference

Crystal structure of Trematomus newnesi haemoglobin re-opens the root effect question., Mazzarella L, D'Avino R, di Prisco G, Savino C, Vitagliano L, Moody PC, Zagari A, J Mol Biol. 1999 Apr 16;287(5):897-906. PMID:10222199 Page seeded by OCA on Sat May 3 09:23:42 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1t1n"
Personal tools