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1t2l

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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t2l OCA], [http://www.ebi.ac.uk/pdbsum/1t2l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t2l RCSB]</span>
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'''Three Crystal Structures of Human Coactosin-like Protein'''
'''Three Crystal Structures of Human Coactosin-like Protein'''
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[[Category: Wang, Y.]]
[[Category: Wang, Y.]]
[[Category: Wei, Z.]]
[[Category: Wei, Z.]]
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[[Category: beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:26:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:23 2008''
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Revision as of 06:26, 3 May 2008

Image:1t2l.jpg

Template:STRUCTURE 1t2l

Three Crystal Structures of Human Coactosin-like Protein


Overview

Human coactosin-like protein is an actin filament binding protein but does not bind to globular actin. It associates with 5-Lipoxygenase both in vivo and in vitro, playing important roles in modulating the activities of actin and 5-Lipoxygenase. Coactosin counteracts the capping activity of capping protein which inhibits the actin polymerization. We determined the crystal structures of human coactosin-like protein by multi-wavelength anomalous dispersion method. The structure showed a high level of similarity to ADF-H domain, although their amino acid sequences share low degree of homology. A few conserved hydrophobic residues that may contribute to the folding were identified. This structure suggests coactosin-like protein bind to F-actin in a different way from ADF/Cofilin family. Combined with the information from previous mutagenesis studies, the binding sites for F-actin and 5-Lipoxygenase were analyzed, respectively. These two sites are quite close, which might prevent F-actin and 5-Lipoxygenase from binding to coactosin simultaneously.

About this Structure

1T2L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human coactosin-like protein., Liu L, Wei Z, Wang Y, Wan M, Cheng Z, Gong W, J Mol Biol. 2004 Nov 19;344(2):317-23. PMID:15522287 Page seeded by OCA on Sat May 3 09:26:17 2008

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