1t3j

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[[Image:1t3j.jpg|left|200px]]
[[Image:1t3j.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1t3j", creates the "Structure Box" on the page.
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|GENE= MFN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_1t3j| PDB=1t3j | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [http://www.ebi.ac.uk/pdbsum/1t3j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB]</span>
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'''Mitofusin domain HR2 V686M/I708M mutant'''
'''Mitofusin domain HR2 V686M/I708M mutant'''
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[[Category: Koshiba, T.]]
[[Category: Koshiba, T.]]
[[Category: McCaffery, J M.]]
[[Category: McCaffery, J M.]]
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[[Category: coiled coil antiparallel]]
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[[Category: Coiled coil antiparallel]]
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[[Category: dimer]]
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[[Category: Dimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:28:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:50:46 2008''
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Revision as of 06:28, 3 May 2008

Image:1t3j.jpg

Template:STRUCTURE 1t3j

Mitofusin domain HR2 V686M/I708M mutant


Overview

Vesicle fusion involves vesicle tethering, docking, and membrane merger. We show that mitofusin, an integral mitochondrial membrane protein, is required on adjacent mitochondria to mediate fusion, which indicates that mitofusin complexes act in trans (that is, between adjacent mitochondria). A heptad repeat region (HR2) mediates mitofusin oligomerization by assembling a dimeric, antiparallel coiled coil. The transmembrane segments are located at opposite ends of the 95 angstrom coiled coil and provide a mechanism for organelle tethering. Consistent with this proposal, truncated mitofusin, in an HR2-dependent manner, causes mitochondria to become apposed with a uniform gap. Our results suggest that HR2 functions as a mitochondrial tether before fusion.

About this Structure

1T3J is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of mitochondrial tethering by mitofusin complexes., Koshiba T, Detmer SA, Kaiser JT, Chen H, McCaffery JM, Chan DC, Science. 2004 Aug 6;305(5685):858-62. PMID:15297672 Page seeded by OCA on Sat May 3 09:28:36 2008

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