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1t44

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[[Image:1t44.gif|left|200px]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t44 OCA], [http://www.ebi.ac.uk/pdbsum/1t44 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1t44 RCSB]</span>
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'''Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation'''
'''Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation'''
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[[Category: Larsson, M.]]
[[Category: Larsson, M.]]
[[Category: Robinson, R C.]]
[[Category: Robinson, R C.]]
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[[Category: structural protein]]
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[[Category: Structural protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:29:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:51:01 2008''
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Revision as of 06:29, 3 May 2008

Image:1t44.gif

Template:STRUCTURE 1t44

Structural basis of actin sequestration by thymosin-B4: Implications for arp2/3 activation


Overview

The WH2 (Wiscott-Aldridge syndrome protein homology domain 2) repeat is an actin interacting motif found in monomer sequestering and filament assembly proteins. We have stabilized the prototypical WH2 family member, thymosin-beta4 (Tbeta4), with respect to actin, by creating a hybrid between gelsolin domain 1 and the C-terminal half of Tbeta4 (G1-Tbeta4). This hybrid protein sequesters actin monomers, severs actin filaments and acts as a leaky barbed end cap. Here, we present the structure of the G1-Tbeta4:actin complex at 2 A resolution. The structure reveals that Tbeta4 sequesters by capping both ends of the actin monomer, and that exchange of actin between Tbeta4 and profilin is mediated by a minor overlap in binding sites. The structure implies that multiple WH2 motif-containing proteins will associate longitudinally with actin filaments. Finally, we discuss the role of the WH2 motif in arp2/3 activation.

About this Structure

1T44 is a Protein complex structure of sequences from Homo sapiens, mus musculus and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins., Irobi E, Aguda AH, Larsson M, Guerin C, Yin HL, Burtnick LD, Blanchoin L, Robinson RC, EMBO J. 2004 Sep 15;23(18):3599-608. Epub 2004 Aug 26. PMID:15329672 Page seeded by OCA on Sat May 3 09:29:54 2008

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