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4f40

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==X-ray crystal structure of Apo prostaglandin f synthase from Leishmania major Friedlin==
==X-ray crystal structure of Apo prostaglandin f synthase from Leishmania major Friedlin==
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<StructureSection load='4f40' size='340' side='right' caption='[[4f40]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='4f40' size='340' side='right'caption='[[4f40]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4f40]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leima Leima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4F40 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4f40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F40 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGFS, LMJF_31_2150 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5664 LEIMA])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f40 OCA], [https://pdbe.org/4f40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f40 RCSB], [https://www.ebi.ac.uk/pdbsum/4f40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f40 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4f40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f40 OCA], [http://pdbe.org/4f40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4f40 RCSB], [http://www.ebi.ac.uk/pdbsum/4f40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4f40 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>
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[https://www.uniprot.org/uniprot/PGFS_LEIMA PGFS_LEIMA] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.<ref>PMID:12633659</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leima]]
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[[Category: Large Structures]]
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[[Category: Prostaglandin-F synthase]]
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[[Category: Leishmania major]]
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[[Category: Structural genomic]]
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[[Category: Nadp]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase]]
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[[Category: Ssgcid]]
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Revision as of 04:33, 7 October 2022

X-ray crystal structure of Apo prostaglandin f synthase from Leishmania major Friedlin

PDB ID 4f40

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