1t6n
From Proteopedia
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'''Crystal structure of the N-terminal domain of human UAP56''' | '''Crystal structure of the N-terminal domain of human UAP56''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Zhao, R.]] | [[Category: Zhao, R.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:35:48 2008'' | |
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Revision as of 06:35, 3 May 2008
Crystal structure of the N-terminal domain of human UAP56
Overview
UAP56 is an essential eukaryotic pre-mRNA splicing factor and mRNA export factor. The mechanisms of its functions are not well understood. We determined the crystal structures of the N- and C-terminal domains of human UAP56 (comprising 90% of the full-length UAP56) at 1.9 A resolution. The two domains each have a RecA-like fold and are connected by a flexible linker. The overall fold of each domain is highly similar to the corresponding domains of eIF4A (a prototypic DExD/H-box protein), with differences at the loops and termini. This structural similarity suggests that UAP56 is likely to possess ATPase and helicase activity similar to eIF4A. The NTP binding pocket of UAP56 is occupied by a citrate ion, mimicking the phosphates of NTP and retaining the P loop in an open conformation. The crystal structure of the N-terminal domain of UAP56 also reveals a dimer interface that is potentially important for UAP56's function.
About this Structure
1T6N is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of UAP56, a DExD/H-box protein involved in pre-mRNA splicing and mRNA export., Zhao R, Shen J, Green MR, MacMorris M, Blumenthal T, Structure. 2004 Aug;12(8):1373-81. PMID:15296731 Page seeded by OCA on Sat May 3 09:35:48 2008
