1t6v
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1t6v.gif|left|200px]] | [[Image:1t6v.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1t6v", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | | | + | --> |
| - | | | + | {{STRUCTURE_1t6v| PDB=1t6v | SCENE= }} |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme''' | '''Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme''' | ||
| Line 31: | Line 28: | ||
[[Category: Stanfield, R L.]] | [[Category: Stanfield, R L.]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
| - | [[Category: | + | [[Category: Immunoglobulin fold]] |
| - | [[Category: | + | [[Category: Protein-protein complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:36:17 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:36, 3 May 2008
Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme
Overview
Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies.
About this Structure
1T6V is a Protein complex structure of sequences from Gallus gallus and Ginglymostoma cirratum. Full crystallographic information is available from OCA.
Reference
Crystal structure of a shark single-domain antibody V region in complex with lysozyme., Stanfield RL, Dooley H, Flajnik MF, Wilson IA, Science. 2004 Sep 17;305(5691):1770-3. Epub 2004 Aug 19. PMID:15319492 Page seeded by OCA on Sat May 3 09:36:17 2008
