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4fzi

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==Crystal structure of prostaglandin F synthase from Trypanosoma cruzi==
==Crystal structure of prostaglandin F synthase from Trypanosoma cruzi==
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<StructureSection load='4fzi' size='340' side='right' caption='[[4fzi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='4fzi' size='340' side='right'caption='[[4fzi]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FZI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FZI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f40|4f40]], [[1vbj|1vbj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzi OCA], [https://pdbe.org/4fzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fzi RCSB], [https://www.ebi.ac.uk/pdbsum/4fzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzi ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tc00.1047053511287.49 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-F_synthase Prostaglandin-F synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.188 1.1.1.188] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fzi OCA], [http://pdbe.org/4fzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fzi RCSB], [http://www.ebi.ac.uk/pdbsum/4fzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fzi ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PGFS_TRYCC PGFS_TRYCC]] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde (By similarity).
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[https://www.uniprot.org/uniprot/PGFS_TRYCC PGFS_TRYCC] Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Prostaglandin-F synthase]]
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[[Category: Large Structures]]
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[[Category: Trycc]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Structural genomic]]
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[[Category: Bimatoprost]]
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[[Category: Eukaryotic pathogen]]
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[[Category: Nadp+]]
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[[Category: Nadph]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Oxidoreductase]]
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[[Category: Parasite]]
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[[Category: Prostaglandin d2]]
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[[Category: Rutin]]
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[[Category: Ssgcid]]
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[[Category: Trypanosomiasis]]
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Revision as of 20:16, 19 October 2022

Crystal structure of prostaglandin F synthase from Trypanosoma cruzi

PDB ID 4fzi

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