1h1w
From Proteopedia
(New page: 200px<br /> <applet load="1h1w" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h1w, resolution 2.00Å" /> '''HIGH RESOLUTION CRY...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1H1W is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, ATP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1W OCA]]. | + | 1H1W is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with SO4, ATP and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.11.1 Transferred entry: 2.7.11.1]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.37 2.7.1.37]]. Structure known Active Site: PIF. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H1W OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 2.7.11.1]] | ||
[[Category: Aalten, D.M.F.Van.]] | [[Category: Aalten, D.M.F.Van.]] | ||
[[Category: Alessi, D.R.]] | [[Category: Alessi, D.R.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:07:53 2007'' |
Revision as of 09:03, 30 October 2007
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HIGH RESOLUTION CRYSTAL STRUCTURE OF THE HUMAN PDK1 CATALYTIC DOMAIN
Overview
3-phosphoinositide dependent protein kinase-1 (PDK1) plays a key role in, regulating signalling pathways by activating AGC kinases such as PKB/Akt, and S6K. Here we describe the 2.0 A crystal structure of the PDK1 kinase, domain in complex with ATP. The structure defines the hydrophobic pocket, termed the "PIF-pocket", which plays a key role in mediating the, interaction and phosphorylation of certain substrates such as S6K1., Phosphorylation of S6K1 at its C-terminal PIF-pocket-interacting motif, promotes the binding of S6K1 with PDK1. In the PDK1 structure, this pocket, is occupied by a crystallographic contact with another molecule of PDK1., Interestingly, close to the PIF-pocket in PDK1, there is an ordered, sulfate ion, interacting tightly with four surrounding side chains. The, ... [(full description)]
About this Structure
1H1W is a [Single protein] structure of sequence from [Homo sapiens] with SO4, ATP and GOL as [ligands]. Active as [Transferred entry: 2.7.11.1], with EC number [2.7.1.37]. Structure known Active Site: PIF. Full crystallographic information is available from [OCA].
Reference
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site., Biondi RM, Komander D, Thomas CC, Lizcano JM, Deak M, Alessi DR, van Aalten DM, EMBO J. 2002 Aug 15;21(16):4219-28. PMID:12169624
Page seeded by OCA on Tue Oct 30 11:07:53 2007
Categories: Homo sapiens | Single protein | Transferred entry: 2.7.11.1 | Aalten, D.M.F.Van. | Alessi, D.R. | Biondi, R.M. | Deak, M. | Komander, D. | Lizcano, J.M. | Thomas, C.C. | ATP | GOL | SO4 | Agc kinase activation | Atp-binding | Phosphoinositide dependent protein kinase | Pi3-kinase signalling | Pif-pocket | Pka | Serine/threonine-protein kinase | Transferase
