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5m1m

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Revision as of 10:58, 12 August 2020

Crystal structure of matrix protein 1 from Influenza C virus (strain C/Ann Arbor/1/1950)

Structural highlights

5m1m is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MAT_INCAA] Ion channel, which might have a role in genome packaging and uncoating processes.^[1]

Publication Abstract from PubMed

Matrix proteins from enveloped viruses play an important role in budding and stabilizing virus particles. In order to assess the role of the matrix protein M1 from influenza C virus (M1-C) in plasma membrane deformation, we have combined structural and in vitro reconstitution experiments with model membranes. We present the crystal structure of the N-terminal domain of M1-C and show by Small Angle X-Ray Scattering analysis that full-length M1-C folds into an elongated structure that associates laterally into ring-like or filamentous polymers. Using negatively charged giant unilamellar vesicles (GUVs), we demonstrate that M1-C full-length binds to and induces inward budding of membrane tubules with diameters that resemble the diameter of viruses. Membrane tubule formation requires the C-terminal domain of M1-C, corroborating its essential role for M1-C polymerization. Our results indicate that M1-C assembly on membranes constitutes the driving force for budding and suggest that M1-C plays a key role in facilitating viral egress.

The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model.,Saletti D, Radzimanowski J, Effantin G, Midtvedt D, Mangenot S, Weissenhorn W, Bassereau P, Bally M Sci Rep. 2017 Jan 25;7:40801. doi: 10.1038/srep40801. PMID:28120862^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Furukawa T, Muraki Y, Noda T, Takashita E, Sho R, Sugawara K, Matsuzaki Y, Shimotai Y, Hongo S. Role of the CM2 protein in the influenza C virus replication cycle. J Virol. 2011 Feb;85(3):1322-9. doi: 10.1128/JVI.01367-10. Epub 2010 Nov 24. PMID:21106743 doi:http://dx.doi.org/10.1128/JVI.01367-10
↑ Saletti D, Radzimanowski J, Effantin G, Midtvedt D, Mangenot S, Weissenhorn W, Bassereau P, Bally M. The Matrix protein M1 from influenza C virus induces tubular membrane invaginations in an in vitro cell membrane model. Sci Rep. 2017 Jan 25;7:40801. doi: 10.1038/srep40801. PMID:28120862 doi:http://dx.doi.org/10.1038/srep40801

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5m1m"

@@ Line 1: / Line 1: @@
 ==Crystal structure of matrix protein 1 from Influenza C virus (strain C/Ann Arbor/1/1950)==
-<StructureSection load='5m1m' size='340' side='right' caption='[[5m1m]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
+<StructureSection load='5m1m' size='340' side='right'caption='[[5m1m]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5m1m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M1M FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5m1m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5M1M FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1m OCA], [http://pdbe.org/5m1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m1m RCSB], [http://www.ebi.ac.uk/pdbsum/5m1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1m ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5m1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1m OCA], [http://pdbe.org/5m1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m1m RCSB], [http://www.ebi.ac.uk/pdbsum/5m1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1m ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Radzimanowski, J]]
 [[Category: Weissenhorn, W]]

5m1m

From Proteopedia

Revision as of 10:58, 12 August 2020

Crystal structure of matrix protein 1 from Influenza C virus (strain C/Ann Arbor/1/1950)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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