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1tbg
From Proteopedia
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'''BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN''' | '''BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN''' | ||
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[[Category: Sigler, P B.]] | [[Category: Sigler, P B.]] | ||
[[Category: Sondek, J S.]] | [[Category: Sondek, J S.]] | ||
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| - | [[Category: | + | [[Category: Prenylation]] |
| - | [[Category: | + | [[Category: Transducer]] |
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Revision as of 06:45, 3 May 2008
BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN
Overview
Many signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (G alpha beta gamma) to convert extracellular signals into intracellular responses. Upon nucleotide exchange catalysed by activated receptors, heterotrimers dissociate into GTP-bound G alpha subunits and G beta gamma dimers, either of which can modulate many downstream effectors. Here we use multiwavelength anomalous diffraction data to solve the crystal structure of the beta gamma dimer of the G protein transducin. The beta-subunit is primarily a seven-bladed beta-propeller that is partially encircled by an extended gamma-subunit. The beta-propeller, which contains seven structurally similar WD repeats, defines the stereochemistry of the WD repeat and the probable architecture of all WD-repeat-containing domains. The structure details interactions between G protein beta- and gamma-subunits and highlights regions implicated in effector modulation for the conserved family of G protein beta gamma dimers.
About this Structure
1TBG is a Protein complex structure of sequences from Bos taurus. The following page contains interesting information on the relation of 1TBG with [G Proteins]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a G-protein beta gamma dimer at 2.1A resolution., Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB, Nature. 1996 Jan 25;379(6563):369-74. PMID:8552196 Page seeded by OCA on Sat May 3 09:45:58 2008
Categories: Bos taurus | G Proteins | Protein complex | Bohm, A. | Hamm, H E. | Lambright, D G. | Sigler, P B. | Sondek, J S. | Eye | Prenylation | Transducer
