5mx1

From Proteopedia

(Difference between revisions)

Revision as of 07:31, 19 August 2020

Crystal structure of human chondroadherin

Structural highlights

5mx1 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CHAD_HUMAN] Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

Publication Abstract from PubMed

The small leucine-rich proteoglycans (SLRPs) are important regulators of extracellular matrix assembly and cell signalling. We have determined crystal structures at ~2.2A resolution of human fibromodulin and chondroadherin, two collagen-binding SLRPs. Their overall fold is similar to that of the prototypical SLRP, decorin, but unlike decorin neither fibromodulin nor chondroadherin forms a stable dimer. A previously identified binding site for integrin alpha2beta1 maps to an alpha-helix in the C-terminal cap region of chondroadherin. Interrogation of the Collagen Toolkits revealed a unique binding site for chondroadherin in collagen II, and no binding to collagen III. A triple-helical peptide containing the sequence GAOGPSGFQGLOGPOGPO (O is hydroxyproline) forms a stable complex with chondroadherin in solution. In fibrillar collagen I and II, this sequence is aligned with the collagen cross-linking site KGHR, suggesting a role for chondroadherin in cross-linking.

Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin.,Paracuellos P, Kalamajski S, Bonna A, Bihan D, Farndale RW, Hohenester E Matrix Biol. 2017 Feb 17. pii: S0945-053X(17)30015-X. doi:, 10.1016/j.matbio.2017.02.002. PMID:28215822^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Paracuellos P, Kalamajski S, Bonna A, Bihan D, Farndale RW, Hohenester E. Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin. Matrix Biol. 2017 Feb 17. pii: S0945-053X(17)30015-X. doi:, 10.1016/j.matbio.2017.02.002. PMID:28215822 doi:http://dx.doi.org/10.1016/j.matbio.2017.02.002

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5mx1"

@@ Line 1: / Line 1: @@
 ==Crystal structure of human chondroadherin==
-<StructureSection load='5mx1' size='340' side='right' caption='[[5mx1]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
+<StructureSection load='5mx1' size='340' side='right'caption='[[5mx1]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5mx1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MX1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5mx1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MX1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5MX1 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx1 OCA], [http://pdbe.org/5mx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx1 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5mx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mx1 OCA], [http://pdbe.org/5mx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mx1 RCSB], [http://www.ebi.ac.uk/pdbsum/5mx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mx1 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 22: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Hohenester, E]]
 [[Category: Paracuellos, P]]

5mx1

From Proteopedia

Revision as of 07:31, 19 August 2020

Crystal structure of human chondroadherin

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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