5mlk
From Proteopedia
(Difference between revisions)
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlk OCA], [http://pdbe.org/5mlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlk RCSB], [http://www.ebi.ac.uk/pdbsum/5mlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlk ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mlk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mlk OCA], [http://pdbe.org/5mlk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mlk RCSB], [http://www.ebi.ac.uk/pdbsum/5mlk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mlk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Biotin-dependent acetyl-CoA carboxylases catalyze the committed step in type II fatty acid biosynthesis, the main route for production of membrane phospholipids in bacteria, and are considered a key target for antibacterial drug discovery. Here we describe the first structure of AccA3, an essential component of the acetyl-CoA carboxylase system in Mycobacterium tuberculosis (MTb). The structure, sequence comparisons, and modeling of ligand-bound states reveal that the ATP cosubstrate-binding site shows distinct differences compared to other bacterial and eukaryotic biotin carboxylases, including all human homologs. This suggests the possibility to design MTb AccA3 subtype-specific inhibitors. DATABASE: Coordinates and structure factors have been deposited in the Protein Data Bank with the accession number 5MLK. | ||
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| + | Crystal structure of the essential biotin-dependent carboxylase AccA3 from Mycobacterium tuberculosis.,Bennett M, Hogbom M FEBS Open Bio. 2017 Apr 4;7(5):620-626. doi: 10.1002/2211-5463.12212. eCollection, 2017 May. PMID:28469974<ref>PMID:28469974</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5mlk" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:03, 17 May 2017
Biotin dependent carboxylase AccA3 dimer from Mycobacterium tuberculosis (Rv3285)
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