Sandbox Reserved 1063

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	== '''DNA Binding''' ==		== '''DNA Binding''' ==
-	DNA Binding occurs in the	+	=== HTH Domain ===
		+
		+	The AdcR MarR transcriptional regulator's structure resembles the other proteins in the same family; however, the most notable differences are found in the winged helix-turn-helix (wHTH) motif that assists in binding DNA. This wHTH motif is consistent among all marR family proteins that bind DNA.
	</StructureSection>		</StructureSection>
	== References ==		== References ==
	<references/>		<references/>

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Revision as of 12:41, 14 March 2017

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.

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Contents 1 3TGN 2 Zinc-Dependent MarR Family Transcriptional Regulator AdcR 2.1 Binding Site 1 2.2 Binding Site 2 3 Mechanism of Action 4 Zinc Ligand(s) 5 Other Ligands 6 DNA Binding 6.1 HTH Domain 7 References

3TGN

Zinc-Dependent MarR Family Transcriptional Regulator AdcR

Write general information about protein here

spinqualitylabelsall models 3TGN Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Zinc-Dependent Transcriptional Regulator AdcR has on each of its two domains (important amino acids for zinc binding shown in white) and can bind a total of four zinc ions at one time. Of the two binding sites, binding site 1 is the only site with known importance for DNA binding. The function of binding site 2 is unknown.

Binding Site 1

consists of a distorted tetrahedral geometry around the zinc ion. The four amino acids involved are E24, H42, H108, and H112.

Binding Site 2

consists of a highly distorted tetrahedral geometry around the zinc ion. There are three amino acids involved in the binding of the zinc ion (C30, E41, and E107) as well as a water molecule.

Mechanism of Action

Zinc Ligand(s)

Other Ligands

DNA Binding

HTH Domain

The AdcR MarR transcriptional regulator's structure resembles the other proteins in the same family; however, the most notable differences are found in the winged helix-turn-helix (wHTH) motif that assists in binding DNA. This wHTH motif is consistent among all marR family proteins that bind DNA.

</StructureSection>

References