1tia

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[[Image:1tia.gif|left|200px]]
[[Image:1tia.gif|left|200px]]
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{{Structure
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|PDB= 1tia |SIZE=350|CAPTION= <scene name='initialview01'>1tia</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1tia", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Triacylglycerol_lipase Triacylglycerol lipase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.3 3.1.1.3] </span>
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{{STRUCTURE_1tia| PDB=1tia | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tia OCA], [http://www.ebi.ac.uk/pdbsum/1tia PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tia RCSB]</span>
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'''AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES'''
'''AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES'''
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[[Category: Wei, Y.]]
[[Category: Wei, Y.]]
[[Category: Yamaguchi, S.]]
[[Category: Yamaguchi, S.]]
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[[Category: hydrolase(carboxylic esterase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:58:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:56:25 2008''
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Revision as of 06:58, 3 May 2008

Image:1tia.gif

Template:STRUCTURE 1tia

AN UNUSUAL BURIED POLAR CLUSTER IN A FAMILY OF FUNGAL LIPASES


Overview

The stability of globular proteins arises largely from the burial of non-polar amino acids in their interior. These residues are efficiently packed to eliminate energetically unfavorable cavities. Contrary to these observations, high resolution X-ray crystallographic analyses of four homologous lipases from filamentous fungi reveal an alpha/beta fold which contains a buried conserved constellation of charged and polar side chains with associated cavities containing ordered water molecules. It is possible that this structural arrangement plays an important role in interfacial catalysis.

About this Structure

1TIA is a Single protein structure of sequence from Penicillium camemberti. Full crystallographic information is available from OCA.

Reference

An unusual buried polar cluster in a family of fungal lipases., Derewenda U, Swenson L, Green R, Wei Y, Dodson GG, Yamaguchi S, Haas MJ, Derewenda ZS, Nat Struct Biol. 1994 Jan;1(1):36-47. PMID:7656005 Page seeded by OCA on Sat May 3 09:58:49 2008

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