5uze

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'''Unreleased structure'''
 
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The entry 5uze is ON HOLD
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==Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182==
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<StructureSection load='5uze' size='340' side='right'caption='[[5uze]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5uze]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clop1 Clop1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5UZE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L1:N-{4-CHLORO-3-[4-(TRIFLUOROMETHYL)-1,3-THIAZOL-2-YL]PHENYL}-N-(2-{3-[(1E)-N-HYDROXYETHANIMIDOYL]PHENYL}PROPAN-2-YL)UREA'>8L1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q32|4q32]], [[4q33|4q33]], [[5uwx|5uwx]], [[5uxe|5uxe]], [[5uzc|5uzc]], [[5uzo|5uzo]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, CPF_2558 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=195103 CLOP1])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5uze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uze OCA], [http://pdbe.org/5uze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uze RCSB], [http://www.ebi.ac.uk/pdbsum/5uze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uze ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/A0A0H2YRZ7_CLOP1 A0A0H2YRZ7_CLOP1]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
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Authors: Maltseva, N., Kim, Y., Mulligan, R., Makowska-Grzyska, M., Gu, M., Gollapalli, D.R., Hedstrom, L., Joachimiak, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
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==See Also==
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
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Description: Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Gollapalli, D.R]]
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[[Category: Clop1]]
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[[Category: Mulligan, R]]
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[[Category: IMP dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Anderson, W F]]
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[[Category: Structural genomic]]
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[[Category: Gollapalli, D R]]
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[[Category: Gu, M]]
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[[Category: Hedstrom, L]]
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[[Category: Joachimiak, A]]
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[[Category: Kim, Y]]
[[Category: Makowska-Grzyska, M]]
[[Category: Makowska-Grzyska, M]]
[[Category: Maltseva, N]]
[[Category: Maltseva, N]]
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[[Category: Joachimiak, A]]
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[[Category: Mulligan, R]]
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[[Category: Hedstrom, L]]
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[[Category: Csgid]]
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[[Category: Anderson, W.F]]
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[[Category: Impdh]]
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[[Category: Gu, M]]
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[[Category: Oxidoreductase]]
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[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Kim, Y]]
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[[Category: Tim barrel]]

Revision as of 08:27, 30 September 2020

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P182

PDB ID 5uze

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