1tkx

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[[Image:1tkx.gif|left|200px]]
[[Image:1tkx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tkx |SIZE=350|CAPTION= <scene name='initialview01'>1tkx</scene>, resolution 2.85&Aring;
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The line below this paragraph, containing "STRUCTURE_1tkx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=GWB:4-[(CYCLOPROPYLETHYNYL)OXY]-6-FLUORO-3-ISOPROPYLQUINOLIN-2(1H)-ONE'>GWB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= POL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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-->
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|DOMAIN=
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{{STRUCTURE_1tkx| PDB=1tkx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tkx OCA], [http://www.ebi.ac.uk/pdbsum/1tkx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tkx RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''
'''CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745'''
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[[Category: Stammers, D K.]]
[[Category: Stammers, D K.]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I.]]
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[[Category: aid]]
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[[Category: Aid]]
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[[Category: drug design]]
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[[Category: Drug design]]
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[[Category: gw490745]]
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[[Category: Gw490745]]
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[[Category: hiv-1 reverse transcriptase]]
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[[Category: Hiv-1 reverse transcriptase]]
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[[Category: nnrti]]
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[[Category: Nnrti]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:04:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:57:29 2008''
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Revision as of 07:04, 3 May 2008

Image:1tkx.gif

Template:STRUCTURE 1tkx

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GW490745


Overview

HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type virus as well as against mutant virus that have been selected by use of current antiretroviral treatment regimens. Based on analogy with known HIV-1 NNRTI inhibitors and modeling studies utilizing the X-ray crystal structure of inhibitors bound in the HIV-1 RT, a series of substituted 2-quinolones was synthesized and evaluated as HIV-1 inhibitors.

About this Structure

1TKX is a Protein complex structure of sequences from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2., Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH, J Med Chem. 2004 Nov 18;47(24):5923-36. PMID:15537347 Page seeded by OCA on Sat May 3 10:04:55 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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