This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5wtq
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human proteasome-assembling chaperone PAC4== | |
| + | <StructureSection load='5wtq' size='340' side='right' caption='[[5wtq]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5wtq]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WTQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WTQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wtq OCA], [http://pdbe.org/5wtq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wtq RCSB], [http://www.ebi.ac.uk/pdbsum/5wtq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wtq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PSMG4_HUMAN PSMG4_HUMAN]] Chaperone protein which promotes assembly of the 20S proteasome. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The 26S proteasome is a large protein complex, responsible for degradation of ubiquinated proteins in eukaryotic cells. Eukaryotic proteasome formation is a highly ordered process that is assisted by several assembly chaperones. The assembly of its catalytic 20S core particle depends on at least five proteasome-specific chaperones, i.e., proteasome-assembling chaperons 1-4 (PAC1-4) and proteasome maturation protein (POMP). The orthologues of yeast assembly chaperones have been structurally characterized, whereas most mammalian assembly chaperones are not. In the present study, we determined a crystal structure of human PAC4 at 1.90-A resolution. Our crystallographic data identify a hydrophobic surface that is surrounded by charged residues. The hydrophobic surface is complementary to that of its binding partner, PAC3. The surface also exhibits charge complementarity with the proteasomal alpha4-5 subunits. This will provide insights into human proteasome-assembling chaperones as potential anticancer drug targets. | ||
| - | + | Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation.,Kurimoto E, Satoh T, Ito Y, Ishihara E, Okamoto K, Yagi-Utsumi M, Tanaka K, Kato K Protein Sci. 2017 May;26(5):1080-1085. doi: 10.1002/pro.3153. Epub 2017 Mar 16. PMID:28263418<ref>PMID:28263418</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5wtq" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
[[Category: Ishihara, E]] | [[Category: Ishihara, E]] | ||
[[Category: Ito, Y]] | [[Category: Ito, Y]] | ||
| + | [[Category: Kato, K]] | ||
| + | [[Category: Kurimoto, E]] | ||
| + | [[Category: Satoh, T]] | ||
| + | [[Category: Tanaka, K]] | ||
| + | [[Category: Chaperone]] | ||
| + | [[Category: Proteasome assembly chaperone]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:16, 24 May 2017
Crystal structure of human proteasome-assembling chaperone PAC4
| |||||||||||
