1tnp

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[[Image:1tnp.jpg|left|200px]]
[[Image:1tnp.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1tnp", creates the "Structure Box" on the page.
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|GENE= NTNC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])
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{{STRUCTURE_1tnp| PDB=1tnp | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tnp OCA], [http://www.ebi.ac.uk/pdbsum/1tnp PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tnp RCSB]</span>
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'''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH'''
'''STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH'''
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[[Category: Gagne, S M.]]
[[Category: Gagne, S M.]]
[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
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[[Category: ef-hand]]
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[[Category: Ef-hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:09:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:58:41 2008''
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Revision as of 07:09, 3 May 2008

Template:STRUCTURE 1tnp

STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH


Overview

Regulation of contraction in skeletal muscle occurs through calcium binding to the protein troponin C. The solution structures of the regulatory domain of apo and calcium-loaded troponin C have been determined by multinuclear, multidimensional nuclear magnetic resonance techniques. The structural transition in the regulatory domain of troponin C on calcium binding involves an opening of the structure through large changes in interhelical angles. This leads to the increased exposure of an extensive hydrophobic patch, an event that triggers skeletal muscle contraction.

About this Structure

1TNP is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structures of the troponin C regulatory domains in the apo and calcium-saturated states., Gagne SM, Tsuda S, Li MX, Smillie LB, Sykes BD, Nat Struct Biol. 1995 Sep;2(9):784-9. PMID:7552750 Page seeded by OCA on Sat May 3 10:09:53 2008

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