1to5

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[[Image:1to5.jpg|left|200px]]
[[Image:1to5.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1to5 |SIZE=350|CAPTION= <scene name='initialview01'>1to5</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1to5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= SOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6183 Schistosoma mansoni])
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-->
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|DOMAIN=
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{{STRUCTURE_1to5| PDB=1to5 | SCENE= }}
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|RELATEDENTRY=[[1to4|1TO4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1to5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1to5 OCA], [http://www.ebi.ac.uk/pdbsum/1to5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1to5 RCSB]</span>
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}}
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'''Structure of the cytosolic Cu,Zn SOD from S. mansoni'''
'''Structure of the cytosolic Cu,Zn SOD from S. mansoni'''
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[[Category: Tanaka, M.]]
[[Category: Tanaka, M.]]
[[Category: Tanaka, T.]]
[[Category: Tanaka, T.]]
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[[Category: beta-barrel]]
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[[Category: Beta-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:10:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:58:50 2008''
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Revision as of 07:10, 3 May 2008

Image:1to5.jpg

Template:STRUCTURE 1to5

Structure of the cytosolic Cu,Zn SOD from S. mansoni


Overview

Cu,Zn superoxide dismutase (Cu,Zn SOD) is an essential enzyme for protecting cells from the toxic effects of reactive oxygen species. In humans, two distinct Cu,Zn SOD genes are located on chromosomes 4 and 21 and mutations in the latter have been associated with familial amyotrophic lateral sclerosis. Similarly, schistosomes (trematode parasites responsible for the chronically debilitating disease schistosomiasis) also produce two distinct Cu,Zn SODs, in this case one cytosolic and one bearing a signal peptide. The crystal structure of the cytosolic form of the enzyme from the human trematode Schistosoma mansoni (SmCtSOD) was solved and refined to a resolution of 2.2 A (space group P2(1)2(1)2(1), R = 17.6% and R(free) = 24.1%) and 1.55 A (space group P2(1), R = 15.7% and R(free) = 17.1%). This is the first report of a crystal structure of a Cu,Zn superoxide dismutase derived from a human parasite. Alternate positions for the catalytic copper and its water ligand were refined for the 1.55 A SmCtSOD model, but the most interesting structural differences between SmCtSOD and the human homologue reside in the loops used for electrostatic guidance of the substrate to the enzyme active site.

About this Structure

1TO5 is a Single protein structure of sequence from Schistosoma mansoni. Full crystallographic information is available from OCA.

Reference

Structure of the cytosolic Cu,Zn superoxide dismutase from Schistosoma mansoni., Cardoso RM, Silva CH, Ulian de Araujo AP, Tanaka T, Tanaka M, Garratt RC, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1569-78. Epub 2004, Aug 26. PMID:15333927 Page seeded by OCA on Sat May 3 10:10:49 2008

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