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1tou

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[[Image:1tou.gif|left|200px]]
[[Image:1tou.gif|left|200px]]
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{{Structure
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|PDB= 1tou |SIZE=350|CAPTION= <scene name='initialview01'>1tou</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1tou", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=B1V:2-[(2-OXO-2-PIPERIDIN-1-YLETHYL)SULFANYL]-6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL'>B1V</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1tou| PDB=1tou | SCENE= }}
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|RELATEDENTRY=[[1tow|1TOW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tou OCA], [http://www.ebi.ac.uk/pdbsum/1tou PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tou RCSB]</span>
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}}
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'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''
'''Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand'''
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[[Category: Rondahl, L.]]
[[Category: Rondahl, L.]]
[[Category: Uppenberg, J.]]
[[Category: Uppenberg, J.]]
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[[Category: lipid-binding]]
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[[Category: Lipid-binding]]
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[[Category: transport]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:12:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:59:04 2008''
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Revision as of 07:12, 3 May 2008

Image:1tou.gif

Template:STRUCTURE 1tou

Crystal structure of human adipocyte fatty acid binding protein in complex with a non-covalent ligand


Overview

The synthesis and biological evaluation of novel human A-FABP inhibitors based on the 6-(trifluoromethyl)pyrimidine-4(1H)-one scaffold is described. Two series of compounds, bearing either an amino or carbon substituent in the 2-position of the pyrimidine ring were investigated. Modification of substituents and chain length optimization led to novel compounds with low micromolar activity and good selectivity for human A-FABP.

About this Structure

1TOU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Substituted benzylamino-6-(trifluoromethyl)pyrimidin-4(1H)-ones: a novel class of selective human A-FABP inhibitors., Ringom R, Axen E, Uppenberg J, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4449-52. PMID:15357970 Page seeded by OCA on Sat May 3 10:12:01 2008

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OCA

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