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==Structure== | ==Structure== | ||
| - | + | YiiP is a homodimer with transmembrane (TMD) and C-terminal (CTD) domains that are connected via a charge interlocking mechanism located on a flexible loop. There are 3 Zn<sup>2+</sup> | |
| + | binding sites per unit of homodimer. Site A is located in the TMD, site C is located in the CTD, and site B is located at the junction of the domains join. Both TMD are composed of 6 helices, 4 of which (TM1,TM2,TM4,TM5) form a pore in which Zn<sup>2+</sup> and H<sup>+</sup> can reach binding Site A. Zn<sup>2+</sup> binding at site C helps hold the CTD together and is thought to stabilize conformational changes in YiiP. | ||
| - | == | + | ==Mechanism of Transport== |
| - | Zn binding to Active Site C causes a conformation change that reduces the affinity for Zn at Active Site A. | ||
| - | == Function == | ||
| - | == | + | ===Zn Induced Conformation Change=== |
| - | == | + | ===Allosteric Inhibition=== |
| + | |||
| + | Zn binding to Active Site C causes a conformation change that reduces the affinity for Zn at Active Site A. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 18:50, 24 March 2017
Zn Transporter YiiP
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
