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Undecaprenyl pyrophosphate synthase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | <StructureSection load='1x07' size=' | + | <StructureSection load='1x07' size='350' side='right' caption='Structure of E. coli UPP complex with isopentenyl pyrophosphate, phosphate and Mg+2 (green) (PDB code [[1x07]]).' scene='59/591995/Cv/4' pspeed='8'> |
== Function == | == Function == | ||
| Line 19: | Line 19: | ||
**[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br /> | **[[1f75]] – UPP (mutant) – ''Micrococcus luteus''<br /> | ||
| - | **[[3qas]], [[5cqb]] – EcUPP – ''Escherichia coli''<br /> | + | **[[3qas]], [[5cqb]], [[5oon]], [[6cb2]] – EcUPP – ''Escherichia coli''<br /> |
**[[1jp3]] – EcUPP (mutant) <br /> | **[[1jp3]] – EcUPP (mutant) <br /> | ||
**[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br /> | **[[2d2r]] – HpUPP (mutant) – ''Helicobacter pylori''<br /> | ||
**[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br /> | **[[2vg4]] – MtUPP – ''Mycobacterium tuberculosis''<br /> | ||
**[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br /> | **[[5kh2]] – SpUPP – ''Streptococcus pneumoniae''<br /> | ||
| + | **[[3wyi]] – SaUPP - ''Staphylococcus aureus'' <br /> | ||
| + | **[[5xk3]] – StUPP – ''Streptmyces''<br /> | ||
*Undecaprenyl pyrophosphate synthase complexes | *Undecaprenyl pyrophosphate synthase complexes | ||
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**[[1ueh]] – EcUPP + Mg + SO4 + triton<br /> | **[[1ueh]] – EcUPP + Mg + SO4 + triton<br /> | ||
**[[1v7u]] – EcUPP + FPP <br /> | **[[1v7u]] – EcUPP + FPP <br /> | ||
| + | **[[4u82]] – EcUPP + Mg + FPP derivative<br /> | ||
**[[1x06]] – EcUPP + Mg + FPP analog + IPP<br /> | **[[1x06]] – EcUPP + Mg + FPP analog + IPP<br /> | ||
**[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br /> | **[[1x08]] – EcUPP (mutant) + Mg + FPP analog + IPP<br /> | ||
| Line 41: | Line 44: | ||
**[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br /> | **[[2vg2]] – MtUPP + Pi + PPi + methyl butenyl diphosphate <br /> | ||
**[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br /> | **[[2vg3]] – MtUPP + Pi + Mg + geranyl diphosphate <br /> | ||
| - | + | **[[5xk8]] – StUPP + GPP <br /> | |
| + | **[[5xk6]] – StUPP + IPP <br /> | ||
| + | **[[5xk7]] – StUPP + DMAPP <br /> | ||
| + | **[[5xk9]] – StUPP + GSPP + DMAPP <br /> | ||
}} | }} | ||
Revision as of 21:28, 4 October 2018
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3D structures of undecaprenyl pyrophosphate synthase
Updated on 04-October-2018
References
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
- ↑ Jukic M, Rozman K, Gobec S. Recent Advances in the Development of Undecaprenyl Pyrophosphate Synthase Inhibitors as Potential Antibacterials. Curr Med Chem. 2016;23(5):464-82. PMID:26718796
- ↑ Guo RT, Ko TP, Chen AP, Kuo CJ, Wang AH, Liang PH. Crystal structures of undecaprenyl pyrophosphate synthase in complex with magnesium, isopentenyl pyrophosphate, and farnesyl thiopyrophosphate: roles of the metal ion and conserved residues in catalysis. J Biol Chem. 2005 May 27;280(21):20762-74. Epub 2005 Mar 23. PMID:15788389 doi:10.1074/jbc.M502121200
