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1ttn
From Proteopedia
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[[Image:1ttn.gif|left|200px]] | [[Image:1ttn.gif|left|200px]] | ||
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'''Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells''' | '''Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hu, H Y.]] | [[Category: Hu, H Y.]] | ||
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| - | [[Category: | + | [[Category: Nmr]] |
| - | [[Category: | + | [[Category: Solution structure]] |
| - | [[Category: | + | [[Category: Ubiquitin-like domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:20:59 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:21, 3 May 2008
Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells
Overview
The previously identified dendritic cell-derived ubiquitin-like protein (DC-UbP) was implicated in cellular differentiation and apoptosis. Sequence alignment suggested that it contains a ubiquitin-like (UbL) domain in the C terminus. Here, we present the solution NMR structure and backbone dynamics of the UbL domain of DC-UbP. The overall structure of the domain is very similar to that of Ub despite low similarity (<30%) in amino-acid sequence. One distinct feature of the domain structure is its highly positively charged surface that is different from the corresponding surfaces of the well-known UbL modifiers, Ub, NEDD8, and SUMO-1. The key amino-acid residues responsible for guiding polyubiquitinated proteins to proteasome degradation in Ub are not conserved in the UbL domain. This implies that the UbL domain of DC-UbP may have its own specific interaction partners with other yet unknown cellular functions related to the Ub pathway.
About this Structure
1TTN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells., Gao YG, Song AX, Shi YH, Chang YG, Liu SX, Yu YZ, Cao XT, Lin DH, Hu HY, Protein Sci. 2005 Aug;14(8):2044-50. Epub 2005 Jun 29. PMID:15987890 Page seeded by OCA on Sat May 3 10:20:59 2008
