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1ttt
From Proteopedia
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[[Image:1ttt.jpg|left|200px]] | [[Image:1ttt.jpg|left|200px]] | ||
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'''PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX''' | '''PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX''' | ||
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[[Category: 1eft]] | [[Category: 1eft]] | ||
[[Category: 4tna]] | [[Category: 4tna]] | ||
| - | [[Category: | + | [[Category: Ef-tu]] |
| - | + | [[Category: Peptide elongation ribonucleoprotein]] | |
| - | [[Category: | + | [[Category: Protein synthesis]] |
| - | [[Category: | + | [[Category: Ribosome]] |
| - | [[Category: | + | [[Category: Trna]] |
| - | [[Category: | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:21:17 2008'' |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 07:21, 3 May 2008
PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX
Overview
The structure of the ternary complex consisting of yeast phenylalanyl-transfer RNA (Phe-tRNAPhe), Thermus aquaticus elongation factor Tu (EF-Tu), and the guanosine triphosphate (GTP) analog GDPNP was determined by x-ray crystallography at 2.7 angstrom resolution. The ternary complex participates in placing the amino acids in their correct order when messenger RNA is translated into a protein sequence on the ribosome. The EF-Tu-GDPNP component binds to one side of the acceptor helix of Phe-tRNAPhe involving all three domains of EF-Tu. Binding sites for the phenylalanylated CCA end and the phosphorylated 5' end are located at domain interfaces, whereas the T stem interacts with the surface of the beta-barrel domain 3. The binding involves many conserved residues in EF-Tu. The overall shape of the ternary complex is similar to that of the translocation factor, EF-G-GDP, and this suggests a novel mechanism involving "molecular mimicry" in the translational apparatus.
About this Structure
1TTT is a Single protein structure of sequence from Thermus aquaticus. The following page contains interesting information on the relation of 1TTT with [Elongation Factors]. Full crystallographic information is available from OCA.
Reference
Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog., Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Reshetnikova L, Clark BF, Nyborg J, Science. 1995 Dec 1;270(5241):1464-72. PMID:7491491 Page seeded by OCA on Sat May 3 10:21:17 2008
