5u04
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u04 OCA], [http://pdbe.org/5u04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u04 RCSB], [http://www.ebi.ac.uk/pdbsum/5u04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u04 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u04 OCA], [http://pdbe.org/5u04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u04 RCSB], [http://www.ebi.ac.uk/pdbsum/5u04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u04 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The current Zika virus (ZIKV) outbreak became a global health threat of complex epidemiology and devastating neurological impacts, therefore requiring urgent efforts towards the development of novel efficacious and safe antiviral drugs. Due to its central role in RNA viral replication, the non-structural protein 5 (NS5) RNA-dependent RNA-polymerase (RdRp) is a prime target for drug discovery. Here we describe the crystal structure of the recombinant ZIKV NS5 RdRp domain at 1.9 A resolution as a platform for structure-based drug design strategy. The overall structure is similar to other flaviviral homologues. However, the priming loop target site, which is suitable for non-nucleoside polymerase inhibitor design, shows significant differences in comparison with the dengue virus structures, including a tighter pocket and a modified local charge distribution. | ||
| + | |||
| + | Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase.,Godoy AS, Lima GM, Oliveira KI, Torres NU, Maluf FV, Guido RV, Oliva G Nat Commun. 2017 Mar 27;8:14764. doi: 10.1038/ncomms14764. PMID:28345596<ref>PMID:28345596</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5u04" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 04:49, 12 April 2017
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
| |||||||||||
Categories: Godoy, A S | Guido, R V.C | Lima, G M.A | Maluf, F V | Oliva, G | Oliveira, K I.Z | Torres, N U | Drug | Ns5 | Polymerase | Rna | Viral protein | Virus | Zika
