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CD44

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<StructureSection load='2jca' size='350' side='right' scene='52/523368/Cv/1' caption='Structure of mouse CD44 hyaluronan-binding domain complex with hyaluronic acid (PDB code [[2jca]])'>
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<StructureSection load='4pz3' size='350' side='right' scene='' caption='Human CD44 hyaluronan-binding domain complex with tetrapeptide (PDB code [[4pz3]])'>
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CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.
CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.
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==3D structures of CD44==
==3D structures of CD44==

Revision as of 13:30, 19 October 2017

Human CD44 hyaluronan-binding domain complex with tetrapeptide (PDB code 4pz3)

Drag the structure with the mouse to rotate

3D structures of CD44

Updated on 19-October-2017

1uuh, 4pz4 – hCD44 hyaluronan-binding domain – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
2jcp - mCD44 hyaluronan-binding domain – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, 4bzc, 4bzk - mCD44 hyaluronan-binding domain + inhibitor
5bzt, 5bzs, 5bzr, 5bzq, 5bzp, 5bzo, 5bzn, 5bzm, 5bzl, 5bzj, 5bzi, 5bzh, 5bzg, 5bzf, 5bze - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide

References

  1. ↑ Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:http://dx.doi.org/10.1107/S2053230X14015532
  2. ↑ Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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