1tve

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[[Image:1tve.gif|left|200px]]
[[Image:1tve.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1tve |SIZE=350|CAPTION= <scene name='initialview01'>1tve</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1tve", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=178:4-(4-HYDROXY-3-ISOPROPYLPHENYLTHIO)-2-ISOPROPYLPHENOL'>178</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Homoserine_dehydrogenase Homoserine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.3 1.1.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= hom6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1tve| PDB=1tve | SCENE= }}
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|RELATEDENTRY=[[1q7g|1Q7G]], [[1ebu|1EBU]], [[1ebf|1EBF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tve FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tve OCA], [http://www.ebi.ac.uk/pdbsum/1tve PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tve RCSB]</span>
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}}
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'''Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol'''
'''Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol'''
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[[Category: Nazi, I.]]
[[Category: Nazi, I.]]
[[Category: Wright, G D.]]
[[Category: Wright, G D.]]
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[[Category: amino acid biosynthesis]]
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[[Category: Amino acid biosynthesis]]
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[[Category: antifungal]]
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[[Category: Antifungal]]
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[[Category: small molecule screening]]
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[[Category: Small molecule screening]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:24:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:38 2008''
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Revision as of 07:24, 3 May 2008

Template:STRUCTURE 1tve

Homoserine Dehydrogenase in complex with 4-(4-hydroxy-3-isopropylphenylthio)-2-isopropylphenol


Overview

A relatively unexploited potential target for antimicrobial agents is the biosynthesis of essential amino acids. Homoserine dehydrogenase, which reduces aspartate semi-aldehyde to homoserine in a NAD(P)H-dependent reaction, is one such target that is required for the biosynthesis of Met, Thr, and Ile from Asp. We report a small molecule screen of yeast homoserine dehydrogenase that has identified a new class of phenolic inhibitors of this class of enzyme. X-ray crystal structural analysis of one of the inhibitors in complex with homoserine dehydrogenase reveals that these molecules bind in the amino acid binding region of the active site and that the phenolic hydroxyl group interacts specifically with the backbone amide of Gly175. These results provide the first nonamino acid inhibitors of this class of enzyme and have the potential to be exploited as leads in antifungal compound design.

About this Structure

1TVE is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

New phenolic inhibitors of yeast homoserine dehydrogenase., Ejim L, Mirza IA, Capone C, Nazi I, Jenkins S, Chee GL, Berghuis AM, Wright GD, Bioorg Med Chem. 2004 Jul 15;12(14):3825-30. PMID:15210149 Page seeded by OCA on Sat May 3 10:24:55 2008

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