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4ovf

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==E. coli sliding clamp in complex with (R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid==
==E. coli sliding clamp in complex with (R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid==
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<StructureSection load='4ovf' size='340' side='right' caption='[[4ovf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='4ovf' size='340' side='right'caption='[[4ovf]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ovf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mc4100 Escherichia coli str. k-12 substr. mc4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OVF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ovf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_str._K-12_substr._MC4100 Escherichia coli str. K-12 substr. MC4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OVF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4OVF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2VG:(2R)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-2-CARBOXYLIC+ACID'>2VG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2VG:(2R)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-2-CARBOXYLIC+ACID'>2VG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ovg|4ovg]], [[4ovh|4ovh]], [[4pnu|4pnu]], [[4pnv|4pnv]], [[4pnw|4pnw]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ovf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovf OCA], [https://pdbe.org/4ovf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ovf RCSB], [https://www.ebi.ac.uk/pdbsum/4ovf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ovf ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BN896_3391, dnaN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1403831 Escherichia coli str. K-12 substr. MC4100])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ovf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ovf OCA], [http://pdbe.org/4ovf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ovf RCSB], [http://www.ebi.ac.uk/pdbsum/4ovf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ovf ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/U6NCW5_ECOLI U6NCW5_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA (By similarity).[PIRNR:PIRNR000804]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ovf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ovf" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[DNA polymerase|DNA polymerase]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Escherichia coli str. K-12 substr. MC4100]]
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[[Category: Escherichia coli str. k-12 substr. mc4100]]
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[[Category: Large Structures]]
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[[Category: Oakley, A J]]
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[[Category: Oakley AJ]]
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[[Category: Yin, Z]]
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[[Category: Yin Z]]
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[[Category: Dnan]]
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[[Category: Poliii beta]]
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[[Category: Sliding clamp]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 07:47, 25 January 2023

E. coli sliding clamp in complex with (R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazole-2-carboxylic acid

PDB ID 4ovf

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