4qpf
From Proteopedia
(Difference between revisions)
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==New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption== | ==New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption== | ||
| - | <StructureSection load='4qpf' size='340' side='right' caption='[[4qpf]], [[Resolution|resolution]] 1.59Å' scene=''> | + | <StructureSection load='4qpf' size='340' side='right'caption='[[4qpf]], [[Resolution|resolution]] 1.59Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QPF FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QPF FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zw5|1zw5]], [[1yq7|1yq7]], [[2vf6|2vf6]], [[3b7l|3b7l]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zw5|1zw5]], [[1yq7|1yq7]], [[2vf6|2vf6]], [[3b7l|3b7l]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [http://pdbe.org/4qpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [http://www.ebi.ac.uk/pdbsum/4qpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [http://pdbe.org/4qpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [http://www.ebi.ac.uk/pdbsum/4qpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Barnett, B L]] | [[Category: Barnett, B L]] | ||
[[Category: Duan, Z]] | [[Category: Duan, Z]] | ||
Revision as of 09:45, 24 April 2019
New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
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Categories: Human | Large Structures | Barnett, B L | Duan, Z | Dunford, J E | Ebetino, F H | Jeans, G | Kwaasi, A A | Lundy, M | Mazur, A | Russell, R G.G | Triffitt, J | All-alpha helical prenyltransferase | Bisphosphonate | Cholesterol synthesis | Dimethylallyl pyrophosphate | Isopentyl pyrophosphate | Isoprene biosynthesis | Isoprenoid pathway | Lipid synthesis | Steroid biosynthesis | Transferase
