Sandbox Reserved 1243

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major organs and metabolic processes and has been found to be linked to some cancers,
major organs and metabolic processes and has been found to be linked to some cancers,
hair loss, and diabetes. L-PGDS can trigger both pro- and anti-inflammatory responses to
hair loss, and diabetes. L-PGDS can trigger both pro- and anti-inflammatory responses to
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the immune system, allowing its levels to be highly regulated.
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the immune system, allowing its levels to be highly regulated. <ref>doi:10.1155/2012/503128</ref>
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>doi:10.1155/2012/503128</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>doi:10.1155/2012/503128</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
== Function ==
== Function ==
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A function of this lovely enzyme is that it is eaten by horrible monsters and then digested in a twisted and malignant fashion.
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== Diseases/Malfunctions!! ==
== Diseases/Malfunctions!! ==
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== Structural highlights ==
== Structural highlights ==
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Disgusting and helical, but definitely without structure, there's no enzyme!
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L-PGDS shares the common beta barrel structure found within the lipocalin family.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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'''I AM IN BOLD!!!'''
 
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dOO DOO DOOdooo!!!!!!
 
Structures to note: ''The Beta Barrel'' in yellow. This is for transferring cookies into my stomach!
Structures to note: ''The Beta Barrel'' in yellow. This is for transferring cookies into my stomach!

Revision as of 19:30, 24 April 2017

This Sandbox is Reserved from Jan 17 through June 31, 2017 for use in the course Biochemistry II taught by Jason Telford at the Maryville University, St. Louis, USA. This reservation includes Sandbox Reserved 1225 through Sandbox Reserved 1244.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

Lipocalin-Type Prostaglandin D Synthase (L-PGDS)

Lipocalin-Type Prostaglandin D Synthase Protein. Beta Barrels shown in Yellow

Drag the structure with the mouse to rotate

Lipocalin-type Prostaglandin D Synthase (L-PGDS) is the second most abundant protein in the human cerebrospinal fluid. It is involved in the transport of hydrophobic molecules as well as its namesake in the production of prostaglandin D2: an unsaturated fatty acid that is involved in maintaining homeostasis, regulating sleep, aiding in inflammatory responses, and other neurological functions. Although structurally and biochemically different from hematopoietic-PGD synthase, they both take part in the arachidonate cyclooxygenase pathway to make PGD from PGH2. The smaller of the two PGD synthases, L-PGDS contains a beta-barrel structure and was initially found in the brain. It was later found in the tissues of the heart, kidneys, and lungs as well as a number of other body fluids. Inhibiting this enzyme results in the deterioration and lack of function of major organs and metabolic processes and has been found to be linked to some cancers, hair loss, and diabetes. L-PGDS can trigger both pro- and anti-inflammatory responses to the immune system, allowing its levels to be highly regulated. [1]


You may include any references to papers as in: the use of JSmol in Proteopedia [2] or to the article describing Jmol [3] to the rescue.

Function

Diseases/Malfunctions!!

It causes the entire world to explode!!!

Relevance

Well, duh, it's affecting the world.

Structural highlights

L-PGDS shares the common beta barrel structure found within the lipocalin family.

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Structures to note: The Beta Barrel in yellow. This is for transferring cookies into my stomach!

</StructureSection>

References

  1. ↑ Joo M, Sadikot RT. PGD synthase and PGD2 in immune resposne. Mediators Inflamm. 2012;2012:503128. doi: 10.1155/2012/503128. Epub 2012 Jun 25. PMID:22791937 doi:http://dx.doi.org/10.1155/2012/503128
  2. ↑ Joo M, Sadikot RT. PGD synthase and PGD2 in immune resposne. Mediators Inflamm. 2012;2012:503128. doi: 10.1155/2012/503128. Epub 2012 Jun 25. PMID:22791937 doi:http://dx.doi.org/10.1155/2012/503128
  3. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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