Sandbox Reserved 1072

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== Structural Overview ==
== Structural Overview ==
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Diguanylate Cyclase exhibits C2 symmetry down its vertical axis.
===GGEEF Domain===
===GGEEF Domain===
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The <scene name='69/694239/Ggeef_domain_dgcz/2'>GGEEF</scene> Domain of Diguanylate Cyclase is the active site of the protein and has two amino acid sequences of GGEEF which allows for binding of two GTP molecules. The Active site can be divided up into two enzymatic <scene name='69/694239/Ggeef_domain_half_site_dgcz/1'>half-sites</scene>, each with a GGEEF domain for binding a single GTP molecule.
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The <scene name='69/694239/Ggeef_domain_dgcz/2'>GGEEF</scene> Domain of Diguanylate Cyclase is the active site of the protein and has two amino acid sequences of GGEEF which allows for binding of two GTP molecules. The Active site can be divided up into two enzymatic <scene name='69/694239/Ggeef_domain_half_site_dgcz/1'>half-sites</scene>, each with a GGEEF domain for binding a single GTP molecule. DgcZ binds the guanine base of GTP through hydrogen bonds to <scene name='69/694239/Gtp_guanine_bonds_asn_asp_dgcz/4'>Asn173 and Asp 182</scene> A Magnesium ion acts as a cofactor for each
===Zinc Binding Domain===
===Zinc Binding Domain===
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Officially residues 19-90.
====3His/1Cys Motif====
====3His/1Cys Motif====
== Mechanism of Action ==
== Mechanism of Action ==

Revision as of 01:34, 31 March 2017

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
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Diguanylate Cyclase DgcZ from Escherichia coli

Diguanylate Cyclase DgcZ

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References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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