1tzd

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[[Image:1tzd.jpg|left|200px]]
[[Image:1tzd.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1tzd |SIZE=350|CAPTION= <scene name='initialview01'>1tzd</scene>, resolution 2.20&Aring;
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The line below this paragraph, containing "STRUCTURE_1tzd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Inositol-trisphosphate_3-kinase Inositol-trisphosphate 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.127 2.7.1.127] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Itpka ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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-->
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|DOMAIN=
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{{STRUCTURE_1tzd| PDB=1tzd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tzd OCA], [http://www.ebi.ac.uk/pdbsum/1tzd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tzd RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE'''
'''CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE'''
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Miller, G J.]]
[[Category: Miller, G J.]]
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[[Category: inositol kinase]]
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[[Category: Inositol kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:33:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:11 2008''
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Revision as of 07:33, 3 May 2008

Image:1tzd.jpg

Template:STRUCTURE 1tzd

CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF INOSITOL 1,4,5-TRISPHOSPHATE 3-KINASE


Overview

Soluble inositol polyphosphates are ubiquitous second messengers in eukaryotes, and their levels are regulated by an array of specialized kinases. The structure of an archetypal member of this class, inositol 1,4,5-trisphosphate 3-kinase (IP3K), has been determined at 2.2 angstroms resolution in complex with magnesium and adenosine diphosphate. IP3K contains a catalytic domain that is a variant of the protein kinase superfamily, and a novel four-helix substrate binding domain. The two domains are in an open conformation with respect to each other, suggesting that substrate recognition and catalysis by IP3K involves a dynamic conformational cycle. The unique helical domain of IP3K blocks access to the active site by membrane-bound phosphoinositides, explaining the structural basis for soluble inositol polyphosphate specificity.

About this Structure

1TZD is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase., Miller GJ, Hurley JH, Mol Cell. 2004 Sep 10;15(5):703-11. PMID:15350215 Page seeded by OCA on Sat May 3 10:33:15 2008

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