This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1tzo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1tzo.gif|left|200px]]
[[Image:1tzo.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1tzo |SIZE=350|CAPTION= <scene name='initialview01'>1tzo</scene>, resolution 3.60&Aring;
+
The line below this paragraph, containing "STRUCTURE_1tzo", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= pagA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 Bacillus anthracis])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1tzo| PDB=1tzo | SCENE= }}
-
|RELATEDENTRY=[[1sht|1SHT]], [[1tzn|1TZN]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tzo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tzo OCA], [http://www.ebi.ac.uk/pdbsum/1tzo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tzo RCSB]</span>
+
-
}}
+
'''Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore'''
'''Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore'''
Line 29: Line 26:
[[Category: Melnyk, R A.]]
[[Category: Melnyk, R A.]]
[[Category: Wigelsworth, D J.]]
[[Category: Wigelsworth, D J.]]
-
[[Category: heptamer]]
+
[[Category: Heptamer]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:33:56 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:03:20 2008''
+

Revision as of 07:33, 3 May 2008

Image:1tzo.gif

Template:STRUCTURE 1tzo

Crystal Structure of the Anthrax Toxin Protective Antigen Heptameric Prepore


Overview

After binding to cellular receptors and proteolytic activation, the protective antigen component of anthrax toxin forms a heptameric prepore. The prepore later undergoes pH-dependent conversion to a pore, mediating translocation of the edema and lethal factors to the cytosol. We describe structures of the prepore (3.6 A) and a prepore:receptor complex (4.3 A) that reveal the location of pore-forming loops and an unexpected interaction of the receptor with the pore-forming domain. Lower pH is required for prepore-to-pore conversion in the presence of the receptor, indicating that this interaction regulates pH-dependent pore formation. We present an example of a receptor negatively regulating pH-dependent membrane insertion.

About this Structure

1TZO is a Single protein structure of sequence from Bacillus anthracis. Full crystallographic information is available from OCA.

Reference

Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation., Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ, Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51. Epub 2004 Aug 23. PMID:15326297 Page seeded by OCA on Sat May 3 10:33:56 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tzo"
Personal tools