This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Trypanothione reductase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
<StructureSection load='4adw' size='450' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene=''>
+
<StructureSection load='4adw' size='450' side='right' caption='Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH [[4adw]]' scene='48/489332/Cv/1' pspeed='8'>
== Function ==
== Function ==
'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor.
'''Trypanothione reductase''' (TTR) is a flavoenzyme which catalyzes the reaction converting trypanothione (TPT) and NADP to trypanothione disulfide and NADPH. TTR uses FAD as cofactor.

Revision as of 10:44, 4 April 2017

Trypanosoma FAD-containing trypanothione reductase dimer complex with trypanothione and NADPH 4adw

Drag the structure with the mouse to rotate

3D structures of trypanothione reductase

Updated on 04-April-2017

References

  1. ↑ Rivarola HW, Paglini-Oliva PA. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution. Curr Drug Targets Cardiovasc Haematol Disord. 2002 Jun;2(1):43-52. PMID:12769656
  2. ↑ Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A. Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography. ChemMedChem. 2013 Jun 3. doi: 10.1002/cmdc.201300176. PMID:23733388 doi:10.1002/cmdc.201300176

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Trypanothione_reductase"
Personal tools