5njk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PTB domain of human Numb isoform-1== | |
| - | + | <StructureSection load='5njk' size='340' side='right' caption='[[5njk]], [[Resolution|resolution]] 3.13Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5njk]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NJK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5njk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5njk OCA], [http://pdbe.org/5njk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5njk RCSB], [http://www.ebi.ac.uk/pdbsum/5njk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5njk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NUMB_HUMAN NUMB_HUMAN]] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Fiore, P P.Di]] | ||
[[Category: Mapelli, M]] | [[Category: Mapelli, M]] | ||
| - | [[Category: | + | [[Category: Breast cancer]] |
| + | [[Category: Endocytosis]] | ||
| + | [[Category: Numb]] | ||
| + | [[Category: Ptb domain]] | ||
Revision as of 06:54, 13 December 2017
PTB domain of human Numb isoform-1
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