1u38

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[[Image:1u38.gif|left|200px]]
[[Image:1u38.gif|left|200px]]
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{{Structure
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|PDB= 1u38 |SIZE=350|CAPTION= <scene name='initialview01'>1u38</scene>
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{{STRUCTURE_1u38| PDB=1u38 | SCENE= }}
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|RELATEDENTRY=[[1u37|1U37]], [[1u39|1U39]], [[1u3b|1U3B]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u38 OCA], [http://www.ebi.ac.uk/pdbsum/1u38 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u38 RCSB]</span>
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'''Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains'''
'''Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains'''
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[[Category: Xia, J.]]
[[Category: Xia, J.]]
[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
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[[Category: pdz domain]]
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[[Category: Pdz domain]]
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[[Category: protein trafficking]]
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[[Category: Protein trafficking]]
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[[Category: scaffold protein]]
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[[Category: Scaffold protein]]
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[[Category: x11s/mint]]
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[[Category: X11s/mint]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:42:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:04:49 2008''
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Revision as of 07:42, 3 May 2008

Image:1u38.gif

Template:STRUCTURE 1u38

Auto-inhibition Mechanism of X11s/Mints Family Scaffold Proteins Revealed by the Closed Conformation of the Tandem PDZ Domains


Overview

Members of the X11/Mint family of multidomain adaptor proteins are composed of a divergent N terminus, a conserved PTB domain and a pair of C-terminal PDZ domains. Many proteins can interact with the PDZ tandem of X11 proteins, although the mechanism of such interactions is unclear. Here we show that the highly conserved C-terminal tail of X11alpha folds back and inserts into the target-binding groove of the first PDZ domain. The binding of this tail occludes the binding of other target peptides. This autoinhibited conformation of X11 requires that the two PDZ domains and the entire C-terminal tail be covalently connected to form an integral structural unit. The autoinhibited conformation of the X11 PDZ tandem provides a mechanistic explanation for the unique target-binding properties of the protein and hints at potential regulatory mechanisms for the X11-target interactions.

About this Structure

1U38 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem., Long JF, Feng W, Wang R, Chan LN, Ip FC, Xia J, Ip NY, Zhang M, Nat Struct Mol Biol. 2005 Aug;12(8):722-8. Epub 2005 Jul 10. PMID:16007100 Page seeded by OCA on Sat May 3 10:42:20 2008

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