1u3l

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[[Image:1u3l.gif|left|200px]]
[[Image:1u3l.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1u3l |SIZE=350|CAPTION= <scene name='initialview01'>1u3l</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1u3l", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CDP:CYTIDINE-5&#39;-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ispF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_1u3l| PDB=1u3l | SCENE= }}
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|RELATEDENTRY=[[1jy8|1Jy8]], [[1u3p|1U3P]], [[1u40|1U40]], [[1u43|1U43]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u3l OCA], [http://www.ebi.ac.uk/pdbsum/1u3l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u3l RCSB]</span>
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}}
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'''IspF with Mg and CDP'''
'''IspF with Mg and CDP'''
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[[Category: Steinbacher, S.]]
[[Category: Steinbacher, S.]]
[[Category: Wungsintaweekul, J.]]
[[Category: Wungsintaweekul, J.]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: mep pathway]]
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[[Category: Mep pathway]]
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[[Category: terpene biosynthesis]]
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[[Category: Terpene biosynthesis]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:43:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:04:57 2008''
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Revision as of 07:43, 3 May 2008

Image:1u3l.gif

Template:STRUCTURE 1u3l

IspF with Mg and CDP


Overview

Isoprenoids are biosynthesized from isopentenyl diphosphate and the isomeric dimethylallyl diphosphate via the mevalonate pathway or a mevalonate-independent pathway that was identified during the last decade. The non-mevalonate pathway is present in many bacteria, some algae and in certain protozoa such as the malaria parasite Plasmodium falciparum and in the plastids of higher plants, but not in mammals and archaea. Therefore, these enzymes have been recognised as promising drug targets. We report the crystal structure of Escherichia coli 2C- methyl-d-erythritol-2,4-cyclodiphosphate synthase (IspF), which converts 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate into 2C-methyl-d-erythritol 2,4-cyclodiphosphate and CMP in a Mg-dependent reaction. The protein forms homotrimers that tightly bind one zinc ion per subunit at the active site, which helps to position the substrate for direct attack of the 2-phosphate group on the beta-phosphate.

About this Structure

1U3L is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase involved in mevalonate-independent biosynthesis of isoprenoids., Steinbacher S, Kaiser J, Wungsintaweekul J, Hecht S, Eisenreich W, Gerhardt S, Bacher A, Rohdich F, J Mol Biol. 2002 Feb 8;316(1):79-88. PMID:11829504 Page seeded by OCA on Sat May 3 10:43:16 2008

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OCA

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