This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5v3m
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==mouseZFP568-ZnF1-11 in complex with DNA== | |
| - | + | <StructureSection load='5v3m' size='340' side='right' caption='[[5v3m]], [[Resolution|resolution]] 2.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5v3m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V3M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V3M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v3g|5v3g]], [[5v3j|5v3j]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v3m OCA], [http://pdbe.org/5v3m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v3m RCSB], [http://www.ebi.ac.uk/pdbsum/5v3m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v3m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ZN568_MOUSE ZN568_MOUSE]] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction (PubMed:22110054, PubMed:27658112). Essential during embryonic development, where it acts as direct repressor of IGF2-P0, placental-specific transcript of IGF2, in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers (PubMed:18701545, PubMed:22110054, PubMed:28522536). Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta (PubMed:18701545, PubMed:21094155). May enhance proliferation or maintenance of neural stem cells (PubMed:23071813).<ref>PMID:18701545</ref> <ref>PMID:21094155</ref> <ref>PMID:22110054</ref> <ref>PMID:23071813</ref> <ref>PMID:27658112</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cheng, X]] | ||
| + | [[Category: Patel, A]] | ||
| + | [[Category: C2h2 type zinc finger]] | ||
| + | [[Category: Dna binding]] | ||
| + | [[Category: Dna binding protein-dna complex]] | ||
| + | [[Category: Transferase-dna complex]] | ||
Revision as of 05:02, 8 March 2018
mouseZFP568-ZnF1-11 in complex with DNA
| |||||||||||
