5v56
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114== | |
| - | + | <StructureSection load='5v56' size='340' side='right' caption='[[5v56]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5v56]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V56 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V56 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=836:N-METHYL-N-[1-[4-(2-METHYLPYRAZOL-3-YL)PHTHALAZIN-1-YL]PIPERIDIN-4-YL]-4-NITRO-2-(TRIFLUOROMETHYL)BENZAMIDE'>836</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v57|5v57]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v56 OCA], [http://pdbe.org/5v56 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v56 RCSB], [http://www.ebi.ac.uk/pdbsum/5v56 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v56 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cherezov, V]] | ||
| + | [[Category: Dharmarajan, V]] | ||
| + | [[Category: Ding, K]] | ||
| + | [[Category: Gati, C]] | ||
| + | [[Category: Griffin, P R]] | ||
| + | [[Category: Han, G W]] | ||
| + | [[Category: Hanson, M A]] | ||
| + | [[Category: Hunter, M S]] | ||
| + | [[Category: Ishchenko, A]] | ||
| + | [[Category: Lin, X]] | ||
| + | [[Category: Nelson, G]] | ||
| + | [[Category: Stevens, R C]] | ||
| + | [[Category: Tan, W]] | ||
| + | [[Category: Tao, H]] | ||
| + | [[Category: Wu, Y]] | ||
| + | [[Category: Xu, F]] | ||
| + | [[Category: Yang, J]] | ||
| + | [[Category: Ye, L]] | ||
| + | [[Category: Zhang, X]] | ||
| + | [[Category: Zhao, F]] | ||
| + | [[Category: Zhao, S]] | ||
| + | [[Category: 7tm domain]] | ||
| + | [[Category: Class f]] | ||
| + | [[Category: Extracellular cystein-rich domain]] | ||
| + | [[Category: Flavodoxin]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Gpcr hedgehog signaling]] | ||
| + | [[Category: Hinge domain]] | ||
| + | [[Category: Human smoothened receptor complex]] | ||
| + | [[Category: Lcp]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Tc114]] | ||
| + | [[Category: Xfel]] | ||
Revision as of 13:51, 24 May 2017
2.9A XFEL structure of the multi-domain human smoothened receptor (with E194M mutation) in complex with TC114
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Categories: Cherezov, V | Dharmarajan, V | Ding, K | Gati, C | Griffin, P R | Han, G W | Hanson, M A | Hunter, M S | Ishchenko, A | Lin, X | Nelson, G | Stevens, R C | Tan, W | Tao, H | Wu, Y | Xu, F | Yang, J | Ye, L | Zhang, X | Zhao, F | Zhao, S | 7tm domain | Class f | Extracellular cystein-rich domain | Flavodoxin | Gpcr | Gpcr hedgehog signaling | Hinge domain | Human smoothened receptor complex | Lcp | Membrane protein | Tc114 | Xfel
