5v5g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4== | |
| - | + | <StructureSection load='5v5g' size='340' side='right' caption='[[5v5g]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5v5g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5V5G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5V5G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5v5h|5v5h]], [[5v5i|5v5i]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5v5g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5v5g OCA], [http://pdbe.org/5v5g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5v5g RCSB], [http://www.ebi.ac.uk/pdbsum/5v5g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5v5g ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/L_CCHFI L_CCHFI]] Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Khare, B]] | ||
| + | [[Category: Mark, B L]] | ||
| + | [[Category: Deubiquitinase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Ovarian tumor domain protease]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Ubiquitin variant]] | ||
Revision as of 13:02, 10 May 2017
OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4
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