5x9j

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'''Unreleased structure'''
 
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The entry 5x9j is ON HOLD until Paper Publication
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==Strucutre of PrhC from Penicillium brasilianum NBRC 6234==
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<StructureSection load='5x9j' size='340' side='right' caption='[[5x9j]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x9j]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5X9J FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5x9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x9j OCA], [http://pdbe.org/5x9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5x9j RCSB], [http://www.ebi.ac.uk/pdbsum/5x9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5x9j ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Trt14 from Aspergillus terreus is involved in unusual skeletal reconstruction during the biosynthesis of the fungal meroterpenoid terretonin. Detailed in vitro characterization revealed that this novel multifunctional enzyme catalyzes not only the D-ring expansion via intramolecular methoxy rearrangement, but also the hydrolysis of the expanded D-ring. The X-ray crystal structures of Trt14, in complex with substrate or product, and two Trt14 homologs, AusH and PrhC from Aspergillus nidulans and Penicillium brasilianum, respectively, indicated similar overall structures to those of the NTF2-like superfamily of enzymes, despite lacking sequence and functional similarities. Moreover, we gained structural insight into the mechanism of the Trt14-catalyzed ring reconstruction from the in-crystal enzyme reaction and site-directed mutagenesis to show that this reaction involves sequential ester bond cleavage and formation. Structural comparison of Trt14 and its homologs suggests that the enzymes in this new superfamily employ similar acid-base chemistry to diversify the molecular architecture of fungal meroterpenoids.
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Authors: Mori, T., Wang, H., Matsuda, Y., Abe, I.
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Molecular basis for the unusual ring reconstruction in fungal meroterpenoid biogenesis.,Mori T, Iwabuchi T, Hoshino S, Wang H, Matsuda Y, Abe I Nat Chem Biol. 2017 Oct;13(10):1066-1073. doi: 10.1038/nchembio.2443. Epub 2017, Jul 31. PMID:28759016<ref>PMID:28759016</ref>
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Description: Strucutre of PrhC from Penicillium brasilianum NBRC 6234
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Mori, T]]
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<div class="pdbe-citations 5x9j" style="background-color:#fffaf0;"></div>
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[[Category: Matsuda, Y]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Abe, I]]
[[Category: Abe, I]]
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[[Category: Matsuda, Y]]
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[[Category: Mori, T]]
[[Category: Wang, H]]
[[Category: Wang, H]]
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[[Category: Isomerase]]
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[[Category: Meroterpenoid]]
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[[Category: Paraherquonin]]

Revision as of 09:15, 4 October 2017

Strucutre of PrhC from Penicillium brasilianum NBRC 6234

5x9j, resolution 2.10Å

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