1u7l

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[[Image:1u7l.jpg|left|200px]]
[[Image:1u7l.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1u7l |SIZE=350|CAPTION= <scene name='initialview01'>1u7l</scene>, resolution 1.75&Aring;
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The line below this paragraph, containing "STRUCTURE_1u7l", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/H(+)-transporting_two-sector_ATPase H(+)-transporting two-sector ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.14 3.6.3.14] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= VMA5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1u7l| PDB=1u7l | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u7l OCA], [http://www.ebi.ac.uk/pdbsum/1u7l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u7l RCSB]</span>
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}}
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'''Crystal Structure of subunit C (vma5p) of the yeast V-ATPase'''
'''Crystal Structure of subunit C (vma5p) of the yeast V-ATPase'''
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==Reference==
==Reference==
Crystal structure of yeast V-ATPase subunit C reveals its stator function., Drory O, Frolow F, Nelson N, EMBO Rep. 2004 Dec;5(12):1148-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15540116 15540116]
Crystal structure of yeast V-ATPase subunit C reveals its stator function., Drory O, Frolow F, Nelson N, EMBO Rep. 2004 Dec;5(12):1148-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15540116 15540116]
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[[Category: H(+)-transporting two-sector ATPase]]
 
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Frolow, F.]]
[[Category: Frolow, F.]]
[[Category: Nelson, N.]]
[[Category: Nelson, N.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:51:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:06:26 2008''
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Revision as of 07:51, 3 May 2008

Image:1u7l.jpg

Template:STRUCTURE 1u7l

Crystal Structure of subunit C (vma5p) of the yeast V-ATPase


Overview

Vacuolar H(+)-ATPase (V-ATPase) has a crucial role in the vacuolar system of eukaryotic cells. It provides most of the energy required for transport systems that utilize the proton-motive force that is generated by ATP hydrolysis. Some, but not all, of the V-ATPase subunits are homologous to those of F-ATPase and the nonhomologous subunits determine the unique features of V-ATPase. We determined the crystal structure of V-ATPase subunit C (Vma5p), which does not show any homology with F-ATPase subunits, at 1.75 A resolution. The structural features suggest that subunit C functions as a flexible stator that holds together the catalytic and membrane sectors of the enzyme. A second crystal form that was solved at 2.9 A resolution supports the flexible nature of subunit C. These structures provide a framework for exploring the unique mechanistic features of V-ATPases.

About this Structure

1U7L is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of yeast V-ATPase subunit C reveals its stator function., Drory O, Frolow F, Nelson N, EMBO Rep. 2004 Dec;5(12):1148-52. PMID:15540116 Page seeded by OCA on Sat May 3 10:51:32 2008

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