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1u8z

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[[Image:1u8z.jpg|left|200px]]
[[Image:1u8z.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1u8z |SIZE=350|CAPTION= <scene name='initialview01'>1u8z</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1u8z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= Rala, Ral-a, Ral ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Saguinus oedipus])
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|DOMAIN=
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{{STRUCTURE_1u8z| PDB=1u8z | SCENE= }}
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|RELATEDENTRY=[[1u8y|1U8Y]], [[1u90|1U90]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8z OCA], [http://www.ebi.ac.uk/pdbsum/1u8z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u8z RCSB]</span>
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'''Crystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap'''
'''Crystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap'''
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[[Category: Nicely, N I.]]
[[Category: Nicely, N I.]]
[[Category: Serrano, V de.]]
[[Category: Serrano, V de.]]
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[[Category: gdp]]
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[[Category: Gdp]]
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[[Category: gmppnp]]
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[[Category: Gmppnp]]
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[[Category: gnp]]
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[[Category: Gnp]]
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[[Category: gppnhp]]
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[[Category: Gppnhp]]
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[[Category: gtp]]
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[[Category: Gtp]]
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[[Category: gtpase]]
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[[Category: Gtpase]]
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[[Category: ral]]
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[[Category: Ral]]
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[[Category: ra]]
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[[Category: Ra]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:54:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:00 2008''
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Revision as of 07:54, 3 May 2008

Image:1u8z.jpg

Template:STRUCTURE 1u8z

Crystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap


Overview

RalA is a GTPase with effectors such as Sec5 and Exo84 in the exocyst complex and RalBP1, a GAP for Rho proteins. We report the crystal structures of Ral-GppNHp and Ral-GDP. Disordered switch I and switch II, located away from crystal contacts, are observed in one of the molecules in the asymmetric unit of the Ral-GppNHp structure. In the other molecule in the asymmetric unit, a second Mg(2+) ion is bound to the GppNHp gamma-phosphate in an environment in which switch I is pulled away from the nucleotide and switch II is found in a tight beta turn. Clustering of conserved residues on the surface of Ral-GppNHp identifies two putative sites for protein-protein interaction. One site is adjacent to switch I. The other is modulated by switch II and is obstructed in Ral-GDP. The Ral structures are discussed in the context of the published structures of the Ral/Sec5 complex, Ras, and Rap.

About this Structure

1U8Z is a Single protein structure of sequence from Saguinus oedipus. Full crystallographic information is available from OCA.

Reference

Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap., Nicely NI, Kosak J, de Serrano V, Mattos C, Structure. 2004 Nov;12(11):2025-36. PMID:15530367 Page seeded by OCA on Sat May 3 10:54:48 2008

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